Neuro-pharmacological effects of Crinum zeylanicum in mice

Authors

  • Adeniyi Yahaya Tijani Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development Idu industrial Area, Abuja, Nigeria
  • Good-luck Jaiyeoba Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development Idu industrial Area, Abuja, Nigeria
  • Isah Marte Hussaini Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria
  • Joseph Akponso Anuka Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria
  • Oluwakanyinsola Adeola Salawu Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development Idu industrial Area, Abuja, Nigeria
Abstract:

Objectives: The aim of present study was to evaluate some effects of Crinum zeylanicum (C. zeylanicum) on central nervous system. Materials and Methods: C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor activity, apomorphine-induced stereotype behaviour, and rota-rod performance. Results: The C. zeylanicum bulb extract significantly and dose-dependently decreased apomorphine-induced hyperactivity in mice (p

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Journal title

volume 2  issue 3

pages  162- 168

publication date 2012-06-01

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